Endocrine Abstracts

Background: Adiponectin is an adipokine with anti-diabetic properties. Recently, retinol binding protein-4 (RBP4) was identified as an adipokine associated with insulin resistance (IR) and a potential marker for type 2 diabetes (T2D) development.Aims: To compare adiponectin and RBP4 circulating levels according to presence/absence of diabetes/prediabetes, in obese women. To study the degree of association of those adipokines with indexes of IR and insuli...

Introduction: Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing’s syndrome (CS) characterized by multiple adrenal nodules >1 cm. It can be diagnosed in patients with overt CS but is more often diagnosed incidentally, especially in the 5th or 6th decades of life.Clinical case: 61-year-old woman with type 2 diabetes, arterial hypertension and dyslipidemia treated with metformin+sitagliptin 1000/50 mg bid, valsartan+hydrochlorot...

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

Introduction: Differentiated thyroid carcinoma is usually associated with a good prognosis. However, some of these tumors (5%) are radioiodine refractory and have different progression, associated with poor prognosis. In these situations, some tyrosine kinase inhibitors (TKI) can be used. We present a clinical case showing the difficulties in the follow-up and treatment of these patients.Clinical case: A 60 years old woman, with a “multicentric papi...

Introduction: Pheochromocytomas/paragangliomas are rare neuroendocrine tumors. Although mostly sporadic, about 1/3 of the cases correspond to inherited autosomal dominant syndromes, often associated with germline mutations of the SDHD, SDHC and SDHB genes. The association with the SDHAF2(SDH5) gene has been recently discovered, with only few cases published worldwide, and it presents as a paraganglioma of the head and neck, without previous known description of other locations...

Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. There are no longitudinal studies of lipid abnormalities in childhood-onset GHD into adulthood. In order to more accurately define the metabolic consequences of GHD in childhood progressing through to adulthood we have examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in Northeast Brazil.1...

IntroductionMetabolic homeostasis in the testis is essential for a healthy spermatogenesis. Insulin is regarded as one of the most important intervenients in the metabolic regulation of spermatogenesis, where it acts directly on the differentiation of spermatogonia into primary spermatocytes or indirectly through the metabolic modulation of Sertoli cells. Additionally, insulin is hypothesized to play a major role on human spermatozoa capacitation, althou...

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...